Akademik Veri Yönetim Sistemi
4. International Congress of Contemporary Pediatric Dentistry, Ankara, Türkiye, 11 - 13 Ekim 2024, cilt.5, ss.23
Aim: Delayed treatment of odontogenic infections may amplify the systemic effects of local infections in children. Studies investigating changes in systemic inflammation markers in children whose dental treatments are neglected are limited. This study aims to investigate the relationship between the severity of chronic apical periodontitis and the parameters of mean platelet volume (MPV), previously studied in relation to various inflammatory diseases, as well as neutrophilic granulocytes (NEUT), lymphocytes (LYMPH), and platelets (PLT). Methods: A total of 104 healthy patients with periapical periodontitis, who underwent dental treatment under general anesthesia (GA) between 01.10.2023 and 01.09.2024, were included in the study. The periapical statuses were dichotomized as mild and severe. Periapical Index (PAI) scores of 2 or 3 were classified as 'mild,' whereas scores of 4 or 5 were classified as 'severe.' Complete blood count (CBC) parameters, including NEUT, LYMPH, PLT, and MPV, were recorded. A significance level of p<0.05 was considered in the study. Results: Of the 104 patients included, 41 were in the mild periapical periodontitis group and 63 in the severe group. The average age of the children was 5.4±1.2 years. The results showed no significant differences between the mild and severe periapical periodontitis groups in terms of LYMPH, PLT, and MPV (p>0.05). However, the NEUT score in the severe periapical periodontitis group was statistically higher than in the mild group (p<0.05). Conclusions: Our study observed that MPV, PLT, and LYMPH biomarkers were not associated with the severity of apical periodontitis, but the NEUT biomarker was elevated in cases of more severe apical periodontitis. This study may serve as a pioneering effort in evaluating the systemic effects of odontogenic infections, which typically manifest as local infections, using CBC parameters. However, more comprehensive, multi-center studies are recommended