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International Journal of Engineering Inventions, vol.13, no.11, pp.62-68, 2024 (Peer-Reviewed Journal)
week 3), 54 Sprague Dawley rats were divided into three main groups, each consisting of twelve animals. For each group, 2 sub-groups were constituted (6 males and 6 females). After slaughtering, adrenal glands were rapidly removed and semi-quantitatively analyzed by conventional histology. The study took placed in the Department of Medical Science Application and Research Center of Ataturk University, Erzurum; Turkey. The rats were sacrificed by decapitation and the left adrenal gland of each animal was dissected out and prepared for morphometric analyses. This investigation describes histological and cytometrical changes of cortical and medullary tissue of adrenal in rats under the acute and chronic stress. Adrenal weight decreased for males and increased for females, respectively, with increasing sress duration. Although volume density of zona glomerulosa and medulla was significantly increased, capsula, zona glomerulosa and zona fasciculata increased, in the treatment groups. We determined that after both stress types and stress duration, the adrenal gland showed histological changes both in the cortical and medullary region.