The genotoxic and oxidative damage potential of olanzapine in vitro

TÜRKEZ H., Togar B.

TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.26, sa.9, ss.583-588, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 9
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1177/0748233710373090
  • Dergi Adı: TOXICOLOGY AND INDUSTRIAL HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.583-588
  • Anahtar Kelimeler: Human lymphocytes, in vitro, olanzapine, sister-chromatid exchange, total antioxidant capacity, total oxidative stress, GLUTATHIONE-S-TRANSFERASE, SCHIZOPHRENIC-PATIENTS, ANTIPSYCHOTIC-DRUGS, LIPID-PEROXIDATION, SODIUM SELENITE, CLOZAPINE, TOXICITY, CELLS, OVERDOSE, STRESS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Olanzapine (OLZ) is an atypical antipsychotic drug and is commonly used for the treatment of schizophrenia and bipolar disorder (BD). However, recent reports indicated that this drug could exhibit cytotoxic effects on nervous and immune systems. To our knowledge, there is scarce data considering the genotoxic or oxidative damage potentials of OLZ on human lymphocyte culture system. Therefore, in this study, the genotoxic potential of OLZ (0 to 160 mu M) have been evaluated in human whole blood cultures (WBCs) related to oxidative status. Sister-chromatid exchange (SCE) test was applied to estimate the DNA damage, and biochemical parameters (total antioxidant capacity [TAC] and total oxidative stress [TOS]) were examined to determine oxidative stress. Our results indicated that the tested antipsychotic drug did not induce SCEs in lymphocytes of treated cultures. However, the application of the highest OLZ concentration caused oxidative stress. It is concluded that the OLZ can be used safely, but it is necessary to consider the tissue damages that are likely to appear depending on the oxidative stress.