New inflammatory markers for prediction of non-dipper blood pressure pattern in patients with essential hypertension: Serum YKL-40/Chitinase 3-like protein 1 levels and echocardiographic epicardial adipose tissue thickness

BAKIRCI E. M., DEĞİRMENCİ H., HAMUR H., Gunay M., GÜLHAN B., Aydin M., ...Daha Fazla

CLINICAL AND EXPERIMENTAL HYPERTENSION, cilt.37, sa.6, ss.505-510, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3109/10641963.2015.1013122
  • Dergi Adı: CLINICAL AND EXPERIMENTAL HYPERTENSION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.505-510
  • Anahtar Kelimeler: Dipper, epicardial adipose tissue, inflammation, non-dipper, YKL-40, FAT THICKNESS, YKL-40 LEVELS, INSULIN-RESISTANCE, PLASMA YKL-40, ASSOCIATION, DYSFUNCTION, BIOMARKER, STROKE, RHYTHM
  • Atatürk Üniversitesi Adresli: Evet

Özet

The aim of the present study was to investigate whether YKL-40 levels and epicardial adipose tissue (EAT) thickness were associated with non-dipping pattern in essential hypertension (HT). Age- and sex-matched 40 dipper hypertensive patients and 40 non-dipper hypertensive patients were included in the study. Non-dippers had significantly increased EAT thickness and higher YKL-40 and high-sensitivity C-reactive protein levels than dippers. Multivariate logistic regression analysis showed that the EAT thickness and serum levels of YKL-40 and high-sensitivity C-reactive protein were independent predictors of non-dipping pattern in essential HT. In essential HT, presence of non-dipping pattern is associated with increased inflammatory response.