Therapeutic effect of vitamin D-3 in a rat diffuse axonal injury model

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Atıf İçin Kopyala

MALCOK U., Sengul G., KADIOGLU H. H., AYDIN I.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.33, sa.1, ss.90-95, 2005 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 33 Sayı: 1
• Basım Tarihi: 2005
• Doi Numarası: 10.1177/147323000503300109
• Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.90-95
• Atatürk Üniversitesi Adresli: Evet

Özet

We investigated the therapeutic effect of vitamin D-3 in a rat diffuse axonal injury model. A total of 60 male Sprague-Dawley rats weighing 175 - 200 g were anaesthetized and subjected to head trauma using Marmarou's impact-acceleration model. The rats were then separated into two groups; one group was treated with vitamin D-3 and the other with saline for up to 4 days after the head trauma. Rats from both groups were killed 1, 3 or 8 days post-injury. The brains were examined histopathologically and scored according to the level of neuronal, vascular and axonal damage. There were no significant differences between the groups after 1 or 3 days, but evaluation after 8 days revealed a significant improvement in the group treated with vitamin D-3. Our data indicate that vitamin D-3 has a beneficial effect in diffuse axonal injury and may be useful in the management of this condition.