The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities

Taslımı P., Kandemir F. M., Demır Y., İleritürk M., Temel Y., Caglayan C., ...Daha Fazla

Journal of Biochemical and Molecular Toxicology, cilt.33, sa.6, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 6
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1002/jbt.22313
  • Dergi Adı: Journal of Biochemical and Molecular Toxicology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: chrysin, cyclophosphamide, enzyme activities, in vivo, metabolic enzymes, rats, ALPHA-GLUCOSIDASE INHIBITORS, POTENT CARBONIC-ANHYDRASE, OXIDATIVE STRESS, ANTIOXIDANT ACTIVITY, CRYSTAL-STRUCTURE, WISTAR RATS, ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE, INFLAMMATION, BROMOPHENOLS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Chrysin (CH) or 5,7-dihydroxyflavone is a flavonoid present in various plants, bee propolis, and honey. Cyclophosphamide (CYP) is a chemotherapeutic drug, which is extensively used in the treatment of multiple human malignancies. In our study, we aimed to investigate the effects of CYP and CH on some metabolic enzymes including carbonic anhydrase, aldose reductase, paraoxonase-1, alpha-glycosidase, acetylcholinesterase, and butyrylcholinesterase enzyme activities in the brain, heart, testis, liver, and kidney tissues of rats. Thirty-five adult male Wistar rats were used. The animals were pretreated with CH (25 and 50 mg/kg b.w.) for seven days before administering a single dose of CYP (200 mg/kg b.w.) on the seventh day. In all the tissues, the treatment of CH significantly regulated these enzyme activities in CYP-induced rats. These results showed that CH exhibited an ameliorative effect against CYP-induced brain, heart, liver, testis, and kidney toxicity.