Antidiabetic potential: in vitro inhibition effects of some natural phenolic compounds on -glycosidase and -amylase enzymes

TASLIMI P., GÜLÇİN İ.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, cilt.31, sa.10, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 10
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1002/jbt.21956
  • Dergi Adı: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: -amylase, -glycosidase, enzyme inhibition, phenolic compounds, ALPHA-GLUCOSIDASE INHIBITORS, HRMS-SPE-NMR, CHIONANTHUS-VIRGINICUS L., ANTIOXIDANT ACTIVITY, ANTIRADICAL ACTIVITIES, POLYPHENOL CONTENT, IDENTIFICATION, ACID, EXTRACT, ACETYLCHOLINESTERASE
  • Atatürk Üniversitesi Adresli: Evet

Özet

-Glycosidase is a catalytic enzyme and it destroys the complex carbohydrates into simple absorbable sugar units. The natural phenolic compounds were tested for their antidiabetic properties as -glycosidase and -amylase inhibitors. The phenolic compounds investigated in this study have been used as antidiabetic common medicines. This paper aimed to consider their capability to inhibit -amylase and -glycosidase, two significant enzymes defined in serum glucose adjustment. These examination recorded impressive inhibition profiles with IC50 values in the range of 137.36-737.23nM against -amylase and 29.01-157.96nM against -glycosidase.