Protective effect of Naringin on experimental hindlimb ischemia/reperfusion injury in rats

GÜRSUL C., Akdemir F. N. E., Akkoyun T., Can I., GÜL M., GÜLÇİN İ.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, cilt.31, ss.56-61, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3109/14756366.2016.1167050
  • Dergi Adı: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.56-61
  • Anahtar Kelimeler: Antioxidant enzymes, ischemia/reperfusion injury, Naringin, reactive oxygen species, skeletal muscle, IN-VITRO ANTIOXIDANT, LYOPHILIZED AQUEOUS EXTRACT, SKELETAL-MUSCLE, POLYPHENOL CONTENT, CAFFEIC ACID, ANTICHOLINERGIC PROPERTIES, LIPID-PEROXIDATION, REPERFUSION INJURY, POTENT INHIBITOR, FLAVONOIDS
  • Atatürk Üniversitesi Adresli: Evet

Özet

This study was designed to investigate the antioxidant effects of Naringin, in ischemia/reperfusion (I/R)-induced skeletal muscle injury in rats. The rats were randomly allocated into three groups including control, I/R and I/R + Naringin groups. Muscle tissues of I/R groups revealed significantly higher antioxidant enzyme activities, and increased levels of malondialdehyde, as specific a marker of the lipid peroxidation and tissue damage, compared to the control group (p<0.05). Levels of these parameters in muscle revealed significant reductions in the I/R + Naringin group compared to the I/R group (p<0.05). Histopathological examination of ischemia muscles in the I/R group showed significant degeneration and inflammation compared to the control group, whereas ischemic muscles of Naringin-administered group showed significant reduction in degeneration and inflammation compared to the I/R group (p<0.05). We suggest that the protective effect of Naringin may reduce the I/R injury in cases of extremity injuries with acute vascular complications, extremity surgery with prolonged tourniquet application.