Site-selective C5-H and N-H alkylation of unprotected 8-aminoquinolines

Turbedaroglu O., Lafzi F., Kilic H.

CHEMICAL COMMUNICATIONS, cilt.58, sa.31, ss.4893-4896, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 31
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1039/d2cc00780k
  • Dergi Adı: CHEMICAL COMMUNICATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, MEDLINE, DIALNET, Index Chemicus (IC), Current Chemical Reactions (CCR)
  • Sayfa Sayıları: ss.4893-4896
  • Atatürk Üniversitesi Adresli: Evet

Özet

8-Aminoquinolines are the building blocks of many pharmaceutical compounds, which has motivated the scientific community to develop new ways to derivatize these compounds. In this work, we performed a site-selective C5-H and N-H alkylation of 8-aminoquinolines using para-quinone methides under extremely mild conditions. C5-H alkylation was performed using protecting group-free 8-aminoquinolines and in metal-free conditions. N-H alkylations were also carried out under mild conditions. All corresponding alkylation products were obtained in high to excellent yields.