Total, free, and bioavailable 25-hydroxyvitamin D levels in patients with periodontitis (stage III): a case–control study

AYDIN T., DİLSİZ A., ÖZKAL EMİNOĞLU D., ŞAHİN A. B., LALOĞLU E., Bayrakdar Y. E.

Clinical Oral Investigations, cilt.27, sa.1, ss.421-430, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 1
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s00784-022-04844-9
  • Dergi Adı: Clinical Oral Investigations
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.421-430
  • Anahtar Kelimeler: Bioavailability, Periodontitis, Vitamin D, Vitamin D-binding protein, VITAMIN-D STATUS, BONE-MINERAL DENSITY, D-BINDING PROTEIN, SERUM CONCENTRATIONS, DISEASE, PLASMA, ASSOCIATION, COMPLEX, ENZYME
  • Atatürk Üniversitesi Adresli: Evet

Özet

© 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.Objective: The aim of this study was to investigate the relationship between total, free and bioavailable 25-hydroxyvitamin D levels, and periodontitis. Materials and methods: Thirty-nine patients with periodontitis diagnosis and 44 healthy participants were included in this study. 25-Hydroxyvitamin D, vitamin D-binding protein, procalcitonin, and albumin levels were measured from the serum samples obtained. Free and bioavailable 25-hydroxyvitamin D levels were calculated. Total, free, and bioavailable 25-hydroxyvitamin D levels were compared between the healthy control and periodontitis groups. The association of total 25 (OH)D levels with periodontitis was tested through univariate analysis and multivariate logistic regression. Results: Total 25-hydroxyvitamin D, bioavailable 25-hydroxyvitamin D, and free 25-hydroxyvitamin D levels were significantly lower in the periodontitis group than in the healthy control group (p < 0.001). In the logistic regression analysis, a significant correlation was observed between total 25-hydroxyvitamin D and periodontitis (p<0.001). Conclusion: Our study shows that there is a relationship between total, free and bioavailable 25-hydroxyvitamin D levels and periodontitis. In addition, it has been shown that the determination of free and bioavailable 25-hydroxyvitamin D levels does not provide additional advantages in terms of the relationship between periodontitis and vitamin D. Clinical relevance: In this case–control study, we examined the relationship between total, free and bioavailable 25-hydroxyvitamin D and periodontitis. We found lower total, free, and bioavailable 25-hydroxyvitamin D levels in periodontitis patients. It was also found that vitamin D-binding protein may be an important biomarker in the identification of various forms of periodontal disease. Trial registration: ClinicalTrials.gov Identifier NCT05343273.