Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis

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Caglayan C., Kandemir F. M., Darendelioglu E., Yıldırım S., Küçükler S., Dörtbudak M. B.

Journal of Trace Elements in Medicine and Biology, cilt.56, ss.60-68, 2019 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.jtemb.2019.07.011
  • Dergi Adı: Journal of Trace Elements in Medicine and Biology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.60-68
  • Anahtar Kelimeler: Apoptosis, Epidermal growth factor receptor, Hepatotoxicity, Inflammation, Mercuric chloride, Rutin, ANTIOXIDANT ACTIVITY, SIGNALING PATHWAY, SODIUM SELENITE, EXPOSURE, LIVER, TOXICITY, LUTEOLIN, EGFR, CYCLOOXYGENASE-2, ACTIVATION
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: Mercury is a global environmental pollutant and is responsible for several organ pathophysiology including oxidative stress-induced liver disorders. Therefore, the present study was conducted to evaluate the potential ameliorative effects of rutin on mercury chloride (HgCl2)-induced hepatotoxicity in adult male rats.