The effects of different mydriatics on intraocular pressure and central corneal thickness in new zealand white rabbits Beyaz yeni zelanda tavşanlarında farklı midriyatiklerin göz içi basıncı ve merkezi kornea kalınlığı üzerine etkileri

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Yanmaz L. E., Okur S., Ersöz U., Şenocak M. G., Doğan E., Okumuş Z.

Kafkas Universitesi Veteriner Fakultesi Dergisi, cilt.27, sa.4, ss.425-429, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.9775/kvfd.2021.25402
  • Dergi Adı: Kafkas Universitesi Veteriner Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, Veterinary Science Database, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.425-429
  • Anahtar Kelimeler: Central corneal thickness, Intraocular pressure, Mydriatic, New Zealand white rabbit, Tropicamide, TOPICAL 1-PERCENT CYCLOPENTOLATE, HORIZONTAL PUPIL DIAMETER, TEAR PRODUCTION, SIZE, TROPICAMIDE, DOGS, PHENYLEPHRINE, VALUES
  • Atatürk Üniversitesi Adresli: Evet

Özet

This study was aimed to compare the effect of 1% atropine, 1% cyclopentolate, 0.5% tropicamide, and 10% phenylephrine eye drops on intraocular pressure (IOP) and central corneal thickness (CCT) in New Zealand White rabbits. Adult male, eight, New Zealand White rabbits were randomly received each of four mydriatic eye drops separately on left eye at a one-week washout period. Each rabbit received all of five different treatments (sterile saline solution, four mydriatic drugs) on the left eye, whereas no measurements were performed on the right eyes during the experiment. The IOP and CCT recordings of rabbits were performed until the pupil returned to normal diameter. The mean CCT values of sterile saline, 1% atropine, 0.5% tropicamide, 1% cyclopentolate, and 10% phenylephrine were 370±15, 368±17, 372±15, 364±18, and 360±17 µm, respectively, and no statistically significant differences (P>0.05) were observed among groups. The mean IOP values of control (sterile saline), 1% atropine, 0.5% tropicamide, 1% cyclopentolate, and 10% phenylephrine as, 9.7±2.1, 10.4±1.8, 10.3±2.1, 11.0±2.1, and 10±1.8 mmHg, respectively, and these were not statistically significant among groups (P>0.05). In conclusion, topical 1% atropine, 0.5% tropicamide 1% cyclopentolate, and 10% phenylephrine do not have significantly effect on IOP and CCT in New Zealand white rabbits.