Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line

Tuncay S., ŞENOL H., GÜLER E. M., Ocal N., SEÇEN H., KOÇYİĞİT A., ...Daha Fazla

MEDICINAL CHEMISTRY, cilt.14, sa.6, ss.617-625, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 6
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1573406414666180222094544
  • Dergi Adı: MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.617-625
  • Anahtar Kelimeler: Triterpenoids, Oleanolic acid, Spectral analysis, Cytotoxicity, Erythrodiol, CANCER CELLS, IN-VITRO, DERIVATIVES, TRITERPENOIDS, INHIBITION, AGENTS, VIVO
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: Oleanolic acid (OA) is a known natural compound with many important biological activities. Thirteen oleanolic acid derivatives linked at C-3 and C-28 were synthesized and their structures were confirmed by H-1- and C-13 NMR and mass spectral analyses. Among them, compounds 4, 6, 8-10, 12, 13 were synthesized for the first time. They were evaluated for their cytotoxic activity. They showed proliferative effect at low concentrations while cytotoxic effect was observed at high concentrations in a dose dependent manner.