Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line
MEDICINAL CHEMISTRY, cilt.14, sa.6, ss.617-625, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 6
- Basım Tarihi: 2018
- Doi Numarası: 10.2174/1573406414666180222094544
- Dergi Adı: MEDICINAL CHEMISTRY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.617-625
- Anahtar Kelimeler: Triterpenoids, Oleanolic acid, Spectral analysis, Cytotoxicity, Erythrodiol
- Atatürk Üniversitesi Adresli: Evet
Özet
Background: Oleanolic acid (OA) is a known natural compound with many important biological activities. Thirteen oleanolic acid derivatives linked at C-3 and C-28 were synthesized and their structures were confirmed by H-1- and C-13 NMR and mass spectral analyses. Among them, compounds 4, 6, 8-10, 12, 13 were synthesized for the first time. They were evaluated for their cytotoxic activity. They showed proliferative effect at low concentrations while cytotoxic effect was observed at high concentrations in a dose dependent manner.