Zhang X., Fan Y., Jing R., Getu M. A., Chen W., Zhang W., ...More
Military Medical Research, vol.11, no.1, pp.1-20, 2024 (SCI-Expanded, Scopus)
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Publication Type:
Article / Article
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Volume:
11
Issue:
1
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Publication Date:
2024
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Doi Number:
10.1186/s40779-024-00535-6
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Journal Name:
Military Medical Research
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Page Numbers:
pp.1-20
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Keywords:
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs), Neuroendocrine neoplasms (NENs), Diagnosis, Chemotherapy, Immunotherapy
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Ataturk University Affiliated:
Yes
Abstract
AbstractNeuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common subtype of NENs. Historically, GEP-NENs have been regarded as infrequent and slow-growing malignancies; however, recent data have demonstrated that the worldwide prevalence and incidence of GEP-NENs have increased exponentially over the last three decades. In addition, an increasing number of studies have proven that GEP-NENs result in a limited life expectancy. These findings suggested that the natural biology of GEP-NENs is more aggressive than commonly assumed. Therefore, there is an urgent need for advanced researches focusing on the diagnosis and management of patients with GEP-NENs. In this review, we have summarized the limitations and recent advancements in our comprehension of the epidemiology, clinical presentations, pathology, molecular biology, diagnosis, and treatment of GEP-NETs to identify factors contributing to delays in diagnosis and timely treatment of these patients.