In vitro effects of rosmarinic acid on glutathione reductase and glucose 6-phosphate dehydrogenase
PHARMACEUTICAL BIOLOGY, cilt.49, sa.6, ss.587-594, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 49 Sayı: 6
- Basım Tarihi: 2011
- Doi Numarası: 10.3109/13880209.2010.533187
- Dergi Adı: PHARMACEUTICAL BIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.587-594
- Anahtar Kelimeler: Enzyme inhibition, kinetics, natural product, purification, NATURAL PHENOLIC-COMPOUNDS, PURIFICATION, BINDING, KIDNEY, ANTIOXIDANT, DERIVATIVES, MECHANISM, SUBSTRATE, KINETICS, AMYLASE
- Atatürk Üniversitesi Adresli: Evet
Özet
Context: Glutathione reductase (GR, NADPH:oxidized glutathione oxidoreductase, E. C 1.6.4.2) is a flavoprotein that catalyzes the NADPH-dependent reduction of oxidized glutathione (GSSG). GR is a crucial enzyme in the antioxidant system by maintaining reduced glutathione (GSH). Glucose 6-phosphate dehydrogenase (G6PD, glucose 6-phosphate (G6P):NADP(+) oxidoreductase, EC 1.1.1.49) is the key regulatory enzyme of the pentose phosphate pathway and maintains NADPH for reductive reactions.