Effects of As2O3 on DNA methylation, genomic instability, and LTR retrotransposon polymorphism in Zea mays

ERTURK F. A., AYDIN M., SIGMAZ B., TAŞPINAR M. S., ARSLAN E., AĞAR G., ...Daha Fazla

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, cilt.22, sa.23, ss.18601-18606, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 23
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/s11356-015-5426-2
  • Dergi Adı: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.18601-18606
  • Anahtar Kelimeler: As2O3, DNA methylation, LTR retrotransposons polymorphism, Genomic instability, Zea mays, INDUCED OXIDATIVE STRESS, SODIUM ARSENITE, IN-VITRO, EXPOSURE, TOXICITY, RESPONSES, PROMOTER, TOBACCO, DAMAGE, HYPERMETHYLATION
  • Atatürk Üniversitesi Adresli: Evet

Özet

Arsenic is a well-known toxic substance on the living organisms. However, limited efforts have been made to study its DNA methylation, genomic instability, and long terminal repeat (LTR) retrotransposon polymorphism causing properties in different crops. In the present study, effects of As2O3 (arsenic trioxide) on LTR retrotransposon polymorphism and DNA methylation as well as DNA damage in Zea mays seedlings were investigated. The results showed that all of arsenic doses caused a decreasing genomic template stability (GTS) and an increasing Random Amplified Polymorphic DNAs (RAPDs) profile changes (DNA damage). In addition, increasing DNA methylation and LTR retrotransposon polymorphism characterized a model to explain the epigenetically changes in the gene expression were also found. The results of this experiment have clearly shown that arsenic has epigenetic effect as well as its genotoxic effect. Especially, the increasing of polymorphism of some LTR retrotransposon under arsenic stress may be a part of the defense system against the stress.