The protective effects of hesperidin and curcumin on 5-fluorouracil-induced nephrotoxicity in mice

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Gelen V., Şengül E., Yıldırım S., Şentürk E., Tekin S., Kükürt A.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, cilt.28, sa.34, ss.47046-47055, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 34
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s11356-021-13969-5
  • Dergi Adı: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, IBZ Online, ABI/INFORM, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Environment Index, Geobase, MEDLINE, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.47046-47055
  • Anahtar Kelimeler: Nephrotoxicity, Apoptosis, Curcumin, Hesperidin, Histopathology, Immunohistochemistry, Mice, OXIDATIVE STRESS, INDUCED TOXICITY, DAMAGE, QUERCETIN, INFLAMMATION, RATS, HEPATOTOXICITY, CHEMOTHERAPY, ANTIOXIDANT, INHIBITION
  • Atatürk Üniversitesi Adresli: Evet

Özet

Nephrotoxicity is a very important complication of 5-fluorouracil (5-FU)-treated cancer patients. Increased oxidative stress, kidney damage, and apoptosis play an important role in the pathogenesis of nephrotoxicity caused by 5-FU. In this study, protective effects of two natural compounds, hesperidin and curcumin, on experimentally induced kidney damage in mice with 5-FU were determined. Application of 5-FU resulted in severe histopathological changes and severe renal failure with increased serum urea and creatinine levels. Also, 5-FU-induced kidney damage, increased levels of malondialdehyde (MDA), decreased superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) activity, and glutathione (GSH) level have been demonstrated. Also, where 5-FU is in the concentration of caspase-3 and 8-OHdG immune-positive cells and therefore causes apoptosis and DNA damage in kidney tissue cells. However, especially high doses of hesperidin and curcumin treatment significantly improved 5-FU-induced oxidative stress/lipid peroxidation, apoptosis/DNA damage, and renal dysfunction. Based on these data, our results suggest that hesperidin and curcumin may be used as new and promising agents against 5-FU-induced nephrotoxicity.