Synthesis, characterization, molecular docking, and biological activities of coumarin-1,2,3-triazole-acetamide hybrid derivatives.

Sepehri N., Mohammadi-Khanaposhtani M., Asemanipoor N., Hosseini S., Biglar M., Larijani B., ...Daha Fazla

Archiv der Pharmazie, cilt.353, sa.10, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 353 Sayı: 10
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1002/ardp.202000109
  • Dergi Adı: Archiv der Pharmazie
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chimica, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: acetylcholinesterase, carbonic anhydrase, coumarin, enzyme inhibition, alpha-glycosidase, CARBONIC-ANHYDRASE INHIBITION, ALPHA-GLUCOSIDASE INHIBITORS, TROUT ONCORHYNCHUS-MYKISS, CHOLINESTERASE-INHIBITORS, POLYPHENOL CONTENTS, CRYSTAL-STRUCTURE, IN-VITRO, COUMARINS, ACETYLCHOLINESTERASE, DESIGN
  • Atatürk Üniversitesi Adresli: Evet

Özet

Coumarins and their derivatives are receiving increasing attention due to numerous biochemical and pharmacological applications. In this study, a series of novel coumarin-1,2,3-triazole-acetamide hybrids was tested against some metabolic enzymes including alpha-glycosidase (alpha-Gly), alpha-amylase (alpha-Amy), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase I (hCA I), and hCA II. The new coumarin-1,2,3-triazole-acetamide hybrids showed K-i values in the range of 483.50-1,243.04 nM against hCA I, 508.55-1,284.36 nM against hCA II, 24.85-132.85 nM against AChE, 27.17-1,104.36 nM against BChE, 590.42-1404.36 nM against alpha-Gly, and 55.38-128.63 nM against alpha-Amy. The novel coumarin-1,2,3-triazoleacetamide hybrids had effective inhibition profiles against all tested metabolic enzymes. Also, due to the enzyme inhibitory effects of the new hybrids, they are potential drug candidates to treat diseases such as epilepsy, glaucoma, type-2 diabetes mellitus (T2DM), Alzheimer's disease (AD), and leukemia. Additionally, these inhibition effects were compared with standard enzyme inhibitors like acetazolamide (for hCA I and II), tacrine (for AChE and BChE), and acarbose (for alpha-Gly and alpha-Amy). Also, those coumarin-1,2,3-triazole-acetamide hybrids with the best inhibition score were docked into the active site of the indicated metabolic enzymes.