The effect of Lacidipine on Ischemia-Reperfusion Induced oxidative damage in ovaries of female rats.

KUMBASAR S., YAPÇA Ö. E., BİLEN H., SÜLEYMAN B., ÖZGERİŞ F. B., BÖREKÇİ B., ...Daha Fazla

BIOMEDICAL RESEARCH-INDIA, cilt.23, sa.4, ss.495-500, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 4
  • Basım Tarihi: 2012
  • Dergi Adı: BIOMEDICAL RESEARCH-INDIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.495-500
  • Anahtar Kelimeler: Lacidipine, ischemia-reperfusion, ovary, rat, CALCIUM, INJURY, TISSUE, METABOLITES, NEUTROPHILS, PREVENTION
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study, we investigated the effects of lacidipine on XO, MDA, MPO, and GSH levels in ovarian tissues of rats, which are subjected to ischemia and post-ischemic reperfusion. In ovarian ischemia (OI), ovarian ischemia-reperfusion (OIR), 2 mg/kg lacidipine + ovarian ischemia (LOI-2), 4 mg/kg lacidipine + ovarian ischemia (LOI-4), 2 mg/kg lacidipine + ovarian ischemia-reperfusion (LOIR-2), 4 mg/kg lacidipine + ovarian ischemia-reperfusion (LOIR-4) and sham-operated healthy control group (HCG); XO 23.8 +/- 0.94, 13.6 +/- 0.76, 8 +/- 0.57, 5.8 +/- 0.60, 4.5 +/- 0.42, 3.6 +/- 0.55, 2.8 +/- 0.30 u/g, respectively, whereas MDA, 4.8 +/- 0.47, 13.33 +/- 0.66, 3.5 +/- 0.35, 3.4 +/- 0.42, 6.0 +/- 0.57, 5.3 +/- 0.61,2.8 +/- 0.22 mu mol/g protein, respectively. MPO, 6.1 +/- 0.60, 14.1 +/- 0.94, 6.3 +/- 0.66, 6.0 +/- 0.73, 8.8 +/- 0.60, 7.5 +/- 0.76, 6 +/- 1.06 u/g protein, respectively, while GSH 8.0 +/- 0.73, 3.1 +/- 0.47, 8.6 +/- 0.95, 8.9 +/- 0.91, 7.1 +/- 0.60, 7.5 +/- 0.76 ,9.1 +/- 0.47 nmol/g protein, respectively. The present study, conducted on the basis of the mechanism of formation of IR injury, demonstrated that lacidipine prevents ischemia-reperfusion injury in the ovarian tissues.