Thrombotic thrombocytopenic purpura: A single - Centre experience

Yildirim R., Bilen Y., KELEŞ M., UYANIK A., ALBAYRAK F., ERDEM F., ...Daha Fazla

TRANSFUSION AND APHERESIS SCIENCE, cilt.43, sa.2, ss.159-162, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.transci.2010.07.007
  • Dergi Adı: TRANSFUSION AND APHERESIS SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.159-162
  • Anahtar Kelimeler: Thrombotic thrombocytopenic purpura, Total plasma exchange, Organ damage, Mortality, VON-WILLEBRAND-FACTOR, FACTOR-CLEAVING PROTEASE, PLASMA-EXCHANGE, ADAMTS13, AUTOANTIBODIES
  • Atatürk Üniversitesi Adresli: Evet

Özet

We aimed to describe the characteristics, treatment regime, and 6-month all-cause mortality of thrombotic thrombocytopenic purpura (TTP) patients treated with total plasma exchange in the our clinic. Thirteen patients were included in the study. Mortality rates of TTP have improved over the last three decades but they are still too high according to modern therapy expectations. Etiology directed treatment should be added to total plasma exchange in secondary TTP cases. Based on TTPs' immunologic etiology, immune modulator and immune suppressor agents have been applied together with total plasma exchange, but mostly in anecdotal case reports or with questionable responses. (C) 2010 Elsevier Ltd. All rights reserved.