A novel approach to contrast-induced nephrotoxicity: the melatonergic agent agomelatine


KARAMAN A. , DİYARBAKIR B., Durur-Subasi I., KÖSE D. , Ozbek-Bilgin A., TOPÇU A., et al.

BRITISH JOURNAL OF RADIOLOGY, cilt.89, 2016 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 89 Konu: 1061
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1259/bjr.20150716
  • Dergi Adı: BRITISH JOURNAL OF RADIOLOGY

Özet

Objective: To study the potential nephroprotective role of agomelatine in rat renal tissue in cases of contrast-induced nephrotoxicity (CIN). The drug's action on the antioxidant system and proinflammatory cytokines, superoxide dismutase (SOD) activity, levels of glutathione (GSH) and malondialdehyde (MDA) and the gene expression of interleukin-6 (IL-6), tumour necrosis factor (TNF)-alpha and nuclear factor kappa B (NF-kappa B) was measured. Tubular necrosis and hyaline and haemorrhagic casts were also histopathologically evaluated.