Pourakbar Farzami S., Uğur Kaplan A. B., Kılınboz Y. F., Çetin M.
PharmATA, cilt.5, sa.1, ss.22-27, 2025 (Hakemli Dergi)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
5
Sayı:
1
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Basım Tarihi:
2025
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Doi Numarası:
10.62425/pharmata.1601090
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Dergi Adı:
PharmATA
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Derginin Tarandığı İndeksler:
EBSCO Legal Source
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Sayfa Sayıları:
ss.22-27
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Atatürk Üniversitesi Adresli:
Evet
Özet
Objective: We aimed to prepare the ethanol extract (Hp-Et) of the aerial parts of Heracleum persicum (Hp) and to determine its antioxidant capacity. We also aimed to develop nanoemulsion (NE) and NE-based gel (NEG) formulations containing this extract for topical application to the skin for wound healing and to characterize these formulations in vitro.
Methods: After the preparation of Hp-Et, its antioxidant capacity was determined by FRAP, CUPRAC, and DPPH methods. Then, blank NE (B-NE) and the extract-containing NE (Hp-Et-NE) formulations were developed and in vitro characterized [morphological analysis; centrifuge test; the determination of droplet size (DtS), polydispersity index (PDI) and zeta potential; viscosity and pH measurements; FT-IR analysis]. Additionally, B-NEG and Hp-Et-NEG were prepared and in vitro characterized [viscosity and pH measurements; FT-IR analysis].
Results: DtS and zeta potential values of NE formulations were around 200 nm and -30 mV, respectively. PDI values were less than 0.4. The pH values for NE and NEG formulations were in the range of 4.63±0.01-5.73±0.01. The NE and NEG formulations showed Newtonian and pseudoplastic behaviors, respectively.
Conclusion: Hp-Et-NEG exhibits the desired pseudoplastic behavior for topical application to the skin.