Genotoxic, antigenotoxic and antioxidant properties of methanol extracts obtained from Peltigera horizontalis and Peltigera praetextata

NARDEMIR G., YANMIS D., Alpsoy L., GÜLLÜCE M., AĞAR G., Aslan A.

Toxicology and Industrial Health, cilt.31, sa.7, ss.602-613, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 7
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1177/0748233713480207
  • Dergi Adı: Toxicology and Industrial Health
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.602-613
  • Anahtar Kelimeler: Peltigera sp., antigenotoxicity, bacterial reverse mutation assay, SCE, antioxidant enzymes, LICHEN SECONDARY METABOLITES, EASTERN ANATOLIA REGION, SODIUM-AZIDE, SACCHAROMYCES-CEREVISIAE, ANTIMUTAGENIC ACTIVITIES, OXIDIZED GLUTATHIONE, MUTAGENIC-ACTIVITY, ESCHERICHIA-COLI, OXIDATIVE STRESS, ACTIVE OXYGEN
  • Atatürk Üniversitesi Adresli: Evet

Özet

Now-a-days, there is a big need to reduce genotoxic effects of mutagenic and carcinogenic agents in environment, which are increased by the technological development. Lichens produce a wide variety of unique metabolites due to being in various extreme areas and being symbiotic organisms of fungi and algae. Therefore, this study was planned to search new sources having antimutagenic activity by researching two different lichen species and to determine whether their usage is safe. With this respect, the mutagenic and antimutagenic properties of methanol extracts of the lichens were determined by the bacterial reverse mutation and sister chromatid exchange assays. Furthermore, the malondialdehyde level, superoxide dismutase, glutathione and glutathione peroxidase activities against aflatoxin BI were determined for understanding the ways in which the lichens showed their genotoxic properties.