Synthesis of Mannich Bases by Two Different Methods and Evaluation of their Acetylcholine Esterase and Carbonic Anhydrase Inhibitory Activities
LETTERS IN DRUG DESIGN & DISCOVERY, cilt.14, sa.5, ss.573-580, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 14 Sayı: 5
- Basım Tarihi: 2017
- Doi Numarası: 10.2174/1570180814666161128120612
- Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.573-580
- Anahtar Kelimeler: Acetylcholine esterase, carbonic anhydrase, conventional heating, Mannich bases, microwave irradiation, DNA TOPOISOMERASE-I, JURKAT CELLS, CORRESPONDING PIPERIDINOLS, CELLULAR GLUTATHIONE, CANCER CELLS, BIOLOGICAL-ACTIVITY, CYTOTOXICITY, DERIVATIVES, HYDROCHLORIDES, DESIGN
- Atatürk Üniversitesi Adresli: Evet
Özet
Background: Mannich bases are an important compounds in medicinal chemistry. They have wide range of biological activities including carbonic anhydrase (CA) inhibitory and acetylcholine esterase inhibitory (AChE) activities.