Synthesis of Mannich Bases by Two Different Methods and Evaluation of their Acetylcholine Esterase and Carbonic Anhydrase Inhibitory Activities

GÜL H. İ., DEMIRTAS A., UCAR G., TASLIMI P., GÜLÇİN İ.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.14, sa.5, ss.573-580, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2174/1570180814666161128120612
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.573-580
  • Anahtar Kelimeler: Acetylcholine esterase, carbonic anhydrase, conventional heating, Mannich bases, microwave irradiation, DNA TOPOISOMERASE-I, JURKAT CELLS, CORRESPONDING PIPERIDINOLS, CELLULAR GLUTATHIONE, CANCER CELLS, BIOLOGICAL-ACTIVITY, CYTOTOXICITY, DERIVATIVES, HYDROCHLORIDES, DESIGN
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: Mannich bases are an important compounds in medicinal chemistry. They have wide range of biological activities including carbonic anhydrase (CA) inhibitory and acetylcholine esterase inhibitory (AChE) activities.