HCA ISOENZYME INHIBITORY ACTIVITIES OF SCHIFF BASES DERIVED FROM CINNAMALDEHYDE AND P-METHOXYCINNAMALDEHYDE
FRESENIUS ENVIRONMENTAL BULLETIN, cilt.27, sa.6, ss.4469-4482, 2018 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 6
- Basım Tarihi: 2018
- Dergi Adı: FRESENIUS ENVIRONMENTAL BULLETIN
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.4469-4482
- Atatürk Üniversitesi Adresli: Evet
Özet
In this study, eight different Schiff base derivatives, derived from cinnamaldehyde and p-methoxycinnamaldehyde were synthesized from the corresponding cinnamaldehydes and anilines via microwave irradiation and their inhibition of activity on the hCA-I and hCA-II isoenzymes were investigated. IC50 values of seven compounds showed to have more stronger inhibitor effects than the reference inhibitor acetazolamide.