Mutagenic and Antimutagenic Effects of Hexane Extract of some Astragalus Species Grown in the Eastern Anatolia Region of Turkey

Gulluce M., Agar G., Baris O., KARADAYI M., ORHAN F., Sahin F.

PHYTOTHERAPY RESEARCH, cilt.24, sa.7, ss.1014-1018, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 7
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1002/ptr.3059
  • Dergi Adı: PHYTOTHERAPY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1014-1018
  • Anahtar Kelimeler: Astragalus, hexane extract, mutagenicity, antimutagenicity, Ames/Salmonella-microsome test, Escherichia coli WP2 test, REVERSE MUTATION ASSAY, SODIUM-AZIDE, ESCHERICHIA-COLI, AMES TEST, ACRIDINES, DNA, ANTIOXIDANT, NITROSAMINES, SYSTEMS, PROTECT
  • Atatürk Üniversitesi Adresli: Evet

Özet

Medical plants and their various extracts have been occasionally used in the treatment of many diseases. Astragalus is one of those medical plants and it has several biological activities. In the present study, the hexane extracts of six Astragalus species, which are grown in the eastern Anatolia region of Turkey, were isolated, and their mutagenic and antimutagenic properties were investigated by using Salmonella typhimurium TA1535, TA1537 and Escherichia coli WP2uvrA tester strains at 0.05, 0.5 and 5 mu g/plate concentrations. Known mutagens sodium aside (NaN3), 9-Aminoacridine (9-AA) and N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG) were used to determine antimutagenic properties of hexane extracts.