Cyclocondensation of amidines with dimethyl acetylenedicarboxylate: A convenient entry into tetramic acids

Erden I., Ozer G., Hoarau C., Cao W.

JOURNAL OF HETEROCYCLIC CHEMISTRY, cilt.43, sa.2, ss.395-399, 2006 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 2
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1002/jhet.5570430220
  • Dergi Adı: JOURNAL OF HETEROCYCLIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.395-399
  • Atatürk Üniversitesi Adresli: Evet

Özet

Amidines undergo cyclocondensations with dimethyl acetylenedicarboxyl ate (DMAD) to give highly functionalized 5-dialkylamino-4-pyrrolin-3-ones. The products are crystalline, highly colored compounds that are uniquely functionalized and represent advanced intermediates in the construction of several other heterocyles, in particular the biologically active tetramic acids. The synthetic transformations of these compounds to tetramic acids are also described.