THE IN VITRO CYTOTOXICITY, GENOTOXICITY AND OXIDATIVE DAMAGE POTENTIAL OF THE ORAL DIPEPTIDYL PEPTIDASE-4 INHIBITOR, LINAGLIPTIN, ON CULTURED HUMAN MONONUCLEAR BLOOD CELLS

Cadirci K., Turkez H., Ozdemir O.

ACTA ENDOCRINOLOGICA-BUCHAREST, cilt.15, sa.1, ss.9-15, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4183/aeb.2019.9
  • Dergi Adı: ACTA ENDOCRINOLOGICA-BUCHAREST
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.9-15
  • Anahtar Kelimeler: DPP-4 inhibitor, linagliptin, cytotoxicity, oxidative stress, genotoxicity, DPP-4 INHIBITORS, GLYCEMIC CONTROL, TYPE-2, SAFETY, TOLERABILITY, SITAGLIPTIN, MANAGEMENT, EFFICACY, THERAPY, STRESS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background. Linagliptin (LNG) is a selective dipeptidyl peptidase-4 (DPP-4) inhibitor that ameliorates blood glucose control of patients with type 2 diabetes, without developing hypoglycemic risk and weight gain with a good clinical and biological tolerance profile. To the best of our knowledge, its cytotoxic, genotoxic and oxidative effects have never been studied on any cell line.