Human monoamine oxidase (hMAO) A and hMAO B inhibitors from Artemisia dracunculus L. herniarin and skimmin: human mononamine oxidase A and B inhibitors from A. dracunculus L.

Aydin T., Akincioglu H., Gumustas M., Gulcin İ., Kazaz C., Cakir A.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, cilt.75, sa.11-12, ss.459-466, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 75 Sayı: 11-12
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1515/znc-2019-0227
  • Dergi Adı: ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.459-466
  • Anahtar Kelimeler: Artemisia dracunculus L., cholinesterase, herniarin, monoamine oxidase, skimmin, CHEMICAL-COMPOSITION, MYCOBACTIN ANALOGS, ETHANOLIC EXTRACT, TARRAGON, COUMARIN, ACETYLCHOLINESTERASE, MAO
  • Atatürk Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate the effects of extracts and pure Artemisia dracunculus L. (tarragon) metabolites on the antimonoamine oxidase and anticholinesterase activities. The compounds were characterized as stigmasterol (1), herniarin (2), (2E,4E)-1-(piperidin-1-yl) undeca-2,4-diene-8,10-diyn-1-one (3), (2E,4E)-N-isobutyl undeca-2,4-Bien-8,10-diynamide (4), 3,4-dehydroherniarin (5) and skimmin (6) by H-1-NMR, C-13-NMR, 1D and 2D NMR methods. The compounds 5 and 6 were isolated from tarragon for the first time. The extracts and pure compounds have inhibitory effects on the human monoamine oxidase (hMAO) A and B enzymes, whereas they did not exhibit any anticholinesterase activities. Among the tarragon compounds, only 2 and 6 compounds showed the inhibitory effects against hMAO A (IC50 = 51.76 and 73.47 mu M, respectively) and hMAO B (IC50 = 0.84 and 1.63 mM, respectively). In the study, herniarin content in the extracts was also analysed by high-performance liquid chromatography and it was found that there was a relationship between the inhibition effects of the extracts and their herniarin content.