Cytotoxic effects of TEGDMA on THP-1 cells in vitro

HARORLI O. T., BAYINDIR Y. Z., ALTUNKAYNAK B. Z., TATAR A.

MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, cilt.14, sa.9, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 9
  • Basım Tarihi: 2009
  • Dergi Adı: MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: TEGDMA, cytotoxicity, apoptosis, necrosis, cell proliferation, monocyte, TRIETHYLENE GLYCOL DIMETHACRYLATE, DENTAL MATERIAL COMPONENTS, RESIN COMPOSITES, OXIDATIVE STRESS, PULP CELLS, APOPTOSIS, MONOCYTES, EXPRESSION, ADHESIVES, SUBLETHAL
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: Resin based dental materials are not stable in the oral environment and may release their components into biological media. These components may include substances such as triethylene glycol dimethacrylate (TEGDMA), which is a major co-monomer of dental resin materials. This release can trigger host immune and inflammatory responses against foreign materials, mediated by monocytes. The aim of this study was to investigate the possible cytotoxic effects of TEGDMA on human THP-1 monocytes.