Interaction of The Immunosuppressive Medications with Other Drugs and Herbal Medicines: Dangers and Pitfalls in Solid Organ Transplantation

Yücelik Ş. S., Satılmış B., Sipahi H., Şahin T. T., Yılmaz S.

INSAC New Trends in Health Science, Mehmet Dalkılıç,Oruç Ali Uğur, Editör, Gece Kitaplığı, Ankara, ss.471-496, 2022

  • Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
  • Basım Tarihi: 2022
  • Yayınevi: Gece Kitaplığı
  • Basıldığı Şehir: Ankara
  • Sayfa Sayıları: ss.471-496
  • Editörler: Mehmet Dalkılıç,Oruç Ali Uğur, Editör
  • Atatürk Üniversitesi Adresli: Evet

Özet

Organ transplantation is increasing all over the world and immunosuppressive drugs are playing an important role during this procedure. Several immunosuppressive drugs such as the calcineurin inhibitors tacrolimus or cyclosporine and the mammalian target of rapamycin inhibitors sirolimus or its derivative everolimus are used to prevent rejection of the implanted organ in solid organ transplantation and suppress immune reactions. The transplant recipients are exposed to traditional medicine and herbal products for various reasons both during pre- and post-transplantation period and they can alter the pharmacodynamics and pharmacokinetics of immunosuppressive medication and leads to interactions. Drug interactions can significantly alter the aim of the immunosuppressive therapy and may lead to a reduction in the therapeutic effect of drugs, increased the risk of serious adverse outcomes like organ rejection, or increase the effect of other drugs that are used together. This can be harmful for the recipients and patients should be informed regarding the potential hazards of such interaction. The present review aims to summarize the mechanism of action, indications of immunosuppressive drugs; also, to evaluate the potential interactions of these drugs with commercially available traditional and alternative herbal medicines.