The Effects of Myricetin Against Testicular and Lung Injury Induced by Testicular Ischemia Reperfusion Model

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Öztürk D., Tanyeli A., Güzel Erdoğan D., Güler M. C., Eraslan E., Baylan H.

Sakarya Medical Journal, cilt.11, sa.1, 2021 (Hakemli Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.31832/smj.783480
  • Dergi Adı: Sakarya Medical Journal
  • Derginin Tarandığı İndeksler: TR DİZİN (ULAKBİM)
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective Testicular torsion may lead to testicular atrophy and male infertility if untreated within some hours. Since ischemia reperfusion (I/R) injury is a reason for the harmful

effects during testicular torsion, antioxidant agents are among the targets of science to deal with reactive oxygen species (ROS). As a flavonoid member, myricetin (3, 3, 4,

5, 5, 7-hexahydroxyflavone, MYR) has antioxidant, anticancer, anti-inflammatory, antiviral, and antidiabetic activities.

Materials

and Methods

In this experiment 32 Wistar albino male rats were randomly divided into 4 groups (n=8). Group I was defined as the sham group. In group II, I/R group, testicular torsion

detorsion was performed. In group III (MYR 25) and group IV (MYR 50), MYR was administrated intraperitoneally at 25 and 50 mg/kg doses, 30 minutes before detorsion.

The testicular and lung tissue samples were examined biochemically.

Results In both testis and lung tissues, MYR decreased TOS, MDA, and MPO levels at both high and low doses compared to the I/R group. Besides, SOD values increased in MYR

treatment groups compared to the I/R group.

Conclusion MYR performed promising effects on testicular and lung tissues following testicular I/R injury according to biochemical parameters.

Keywords myricetin; torsion detorsion; ischemia reperfusion; testis; lung.