Effects of umbelliferone isolated from the Ferulago pauciradiata Boiss. & Heldr. Plant on cecal ligation and puncture-induced sepsis model in rats

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Kutlu Z., Çelik M., Bilen A., Halıcı Z., Yıldırım S., Karabulut S., ...Daha Fazla

BIOMEDICINE & PHARMACOTHERAPY, cilt.127, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 127
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.biopha.2020.110206
  • Dergi Adı: BIOMEDICINE & PHARMACOTHERAPY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Antioxidant, CLP, IL-1, TNF-alpha, Umbelliferone, OXIDATIVE STRESS, DNA-DAMAGE, LIVER, MECHANISMS, EXPRESSION, PROTECTS, KIDNEY, INJURY, ASSAY, ACID
  • Atatürk Üniversitesi Adresli: Evet

Özet

Sepsis is a pathophysiological event involving systemic inflammatory response syndrome, multiple organ failure syndromes, and tissue damage. Overproduction of free radicals as a result of tissue damage during sepsis contributes to cellular toxicity, organ failure, and even mortality. Antioxidants, which scavenge free radicals, play a protective role against various diseases. Previous studies have shown that umbelliferone (UF) has antioxidant and anti-inflammatory effects. Since oxidative stress is naturally associated with sepsis-induced organ dysfunction, the application of antioxidant compounds could potentially illuminate the pathophysiology of sepsis, which does not yet have an effective treatment.