Effects of umbelliferone isolated from the Ferulago pauciradiata Boiss. & Heldr. Plant on cecal ligation and puncture-induced sepsis model in rats
BIOMEDICINE & PHARMACOTHERAPY, vol.127, 2020 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 127
- Publication Date: 2020
- Doi Number: 10.1016/j.biopha.2020.110206
- Journal Name: BIOMEDICINE & PHARMACOTHERAPY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
- Keywords: Antioxidant, CLP, IL-1, TNF-alpha, Umbelliferone
- Open Archive Collection: AVESIS Open Access Collection
- Ataturk University Affiliated: Yes
Abstract
Sepsis is a pathophysiological event involving systemic inflammatory response syndrome, multiple organ failure syndromes, and tissue damage. Overproduction of free radicals as a result of tissue damage during sepsis contributes to cellular toxicity, organ failure, and even mortality. Antioxidants, which scavenge free radicals, play a protective role against various diseases. Previous studies have shown that umbelliferone (UF) has antioxidant and anti-inflammatory effects. Since oxidative stress is naturally associated with sepsis-induced organ dysfunction, the application of antioxidant compounds could potentially illuminate the pathophysiology of sepsis, which does not yet have an effective treatment.