Effects of Polygonum cognatum Meissn. extract on indomethacin induced gastric damage in rats

BAYIR Y., Tagiyeva N., ALBAYRAK A., Ismayilov A., AKPINAR E., TOKTAY E., ...Daha Fazla

BIOTECHNIC & HISTOCHEMISTRY, cilt.98, sa.6, ss.424-431, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 98 Sayı: 6
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1080/10520295.2023.2221040
  • Dergi Adı: BIOTECHNIC & HISTOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.424-431
  • Anahtar Kelimeler: Antioxidants, phytotherapy, Polygonum cognatum, rat, stomach, ulcer, OXIDATIVE STRESS, ULCER, ACID, ASSAY
  • Atatürk Üniversitesi Adresli: Evet

Özet

We investigated the anti-ulcer activity of ethanol extracts of Polygonum cognatum on indomethacin induced gastric damage in rats. We evaluated the number of ulcer areas, oxidant and antioxidant parameters as well as histopathologic features in rat stomach. We measured the total antioxidant status of P. cognatum in concentrations from 1.56-100 mg/ml. P. cognatum extract inhibited indomethacin induced ulcer formation with an effect similar to a 20 mg/kg dose of the standard anti-ulcer drug, esomeprazole. All doses of P. cognatum extract exhibited positive effects on oxidative stress markers and histopathological features in the stomach tissue of rats. We suggest that the antioxidant activity of P. cognatum extract may be responsible for its gastroprotective effect and that P. cognatum extract may be a useful gastroprotective agent.