Factors Associated with Mortality in Hospitalized Older Adults

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TOSUN TAŞAR P., ŞAHİN S., Karasahin O., ÜNEŞ M., Ozturk Z. K., Aykar F. S.

NAMIK KEMAL MEDICAL JOURNAL, no.3, pp.219-225, 2023 (ESCI) identifier


Aim: This study aimed to evaluate mortality risk associated with readily accessible laboratory parameters and underlying conditions in hospitalized older adults. Materials and Methods: This retrospective study included geriatric patients admitted for inpatient care to the internal medicine wards of two major university hospitals in two different regions of Turkey. Data related to the patients were collected by retrospective review of patient charts and electronic records. Survival data were obtained from the Death Reporting System of the Turkish Ministry of Health. Survival after admission at 30 days and 1 year was noted. Results: The study included 1.465 hospitalized older adults with a median age of 74 years, of whom 51% were women. Of these patients, 115 (7.8%) died within 30 days and 382 (26.1%) died within 12 months. For 30-day mortality, independent risk factors appeared to be infectious diseases [odds ratio (OR) 2.109, p=0.006], receiving palliative support (OR 5.982, p=0.006), malignancy (OR 2.514, p=0.001), Charlson Comorbidity Index (CCI) (OR 1.219 per unit increase, p<0.001), MPV (OR 1.525 per unit increase, p<0.001), and CRP (OR 1.006 per unit increase, p<0.001). For 12-month mortality, independent risk factors were found to be infectious diseases (OR 1.978, p=0.01), palliative support (OR 6.506, p<0.001), malignancy (OR 2.654, p<0.001), CCI (OR 1.200 per unit increase, p<0.001), and CRP (OR 1.006 per unit increase, p<0.001). Conclusion: The results of this study show that CCI, CRP, and NLR were associated with higher mortality both at 30 days and 12 months. A one-unit increase in MPV was an independent risk factor for 30-day mortality and increased the odds of mortality by 52.5%.