Synthesis of C-13 labeled beta-cyano-L-alanine Nesa Ghasemi and Hasan Secen
ORGANIC COMMUNICATIONS, cilt.10, sa.1, ss.6-10, 2017 (ESCI, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 10 Sayı: 1
- Basım Tarihi: 2017
- Doi Numarası: 10.25135/acg.oc.2.16.08.502
- Dergi Adı: ORGANIC COMMUNICATIONS
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
- Sayfa Sayıları: ss.6-10
- Atatürk Üniversitesi Adresli: Evet
Özet
A synthetic methodology for preparation of beta-cyano-L-alanine was developed via L-serine. Esterification of L -serine with MeOH, followed by protection of NH2 with CBz, gave methyl 2-(benzyloxycarbonylamino)-3-hydroxypropanoate. Mesylation of OH group, and then cyanation, ester hydrolysis and removal of the CBz group with catalytic hydrogenation, gave beta-cyano-L-alanine. Crucial step for the synthesis of the title compound was cyanation with (KCN)-C-13.