Synthesis and Anticancer Activity of Novel Ureas and Sulfamides Incorporating 1-Aminotetralins

ÖZGERİŞ B., AKBABA Y., Ozdemir O., TÜRKEZ H., GÖKSU S.

ARCHIVES OF MEDICAL RESEARCH, cilt.48, sa.6, ss.513-519, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.arcmed.2017.12.002
  • Dergi Adı: ARCHIVES OF MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.513-519
  • Anahtar Kelimeler: Sulfamide, Urea, Aminotetralin, Anticancer activity, PC-3 cell line, U-87MG cell line, ANHYDRASE INHIBITORY PROPERTIES, CYTO-TOXICITY, DERIVATIVES, ANALOGS, ASSAY
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background and Aims. In the present study, a series of ureas and sulfamides derived from 1-aminotetralins were synthesized. For this purpose, urea and sulfamide analogues were synthesized from the reactions of substituted 1-aminotetralins with N,N-dimethylcarbamoyl chloride and N,N-dimethylsulfamoyl chloride. The anticancer activity of newly synthesized compounds was tested against human U-87MG glioblastoma and PC-3 prostate cancer cell lines. Cytotoxicity was examined using MTT and LDH release assays.