Synthesis and Anticancer Activity of Novel Ureas and Sulfamides Incorporating 1-Aminotetralins
ARCHIVES OF MEDICAL RESEARCH, cilt.48, sa.6, ss.513-519, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 48 Sayı: 6
- Basım Tarihi: 2017
- Doi Numarası: 10.1016/j.arcmed.2017.12.002
- Dergi Adı: ARCHIVES OF MEDICAL RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.513-519
- Anahtar Kelimeler: Sulfamide, Urea, Aminotetralin, Anticancer activity, PC-3 cell line, U-87MG cell line, ANHYDRASE INHIBITORY PROPERTIES, CYTO-TOXICITY, DERIVATIVES, ANALOGS, ASSAY
- Atatürk Üniversitesi Adresli: Evet
Özet
Background and Aims. In the present study, a series of ureas and sulfamides derived from 1-aminotetralins were synthesized. For this purpose, urea and sulfamide analogues were synthesized from the reactions of substituted 1-aminotetralins with N,N-dimethylcarbamoyl chloride and N,N-dimethylsulfamoyl chloride. The anticancer activity of newly synthesized compounds was tested against human U-87MG glioblastoma and PC-3 prostate cancer cell lines. Cytotoxicity was examined using MTT and LDH release assays.