The Comparative Efficacy of Intravenous Ibuprofen 400 mg and 800 mg in Acute Mechanical Low Back Pain: A Prospective, Randomized, Double-Blind Clinical Study Acil Serviste Akut Mekanik Bel Ağrılarında Ibuprofen 400 Mg and 800 Mg Intravenöz Formlarının Analjezik Etkilerinin Karşılaştırılması: Prospektif, Randomize Klinik ve Çift Kör Çalışma

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Dönmez S., TEKİN E., Erdem A. B., Şener A., Tümer M., Yilmaz M., ...Daha Fazla

Journal of Midwifery and Health Sciences, cilt.7, sa.2, ss.309-316, 2024 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 2
  • Basım Tarihi: 2024
  • Doi Numarası: 10.62425/esbder.1509208
  • Dergi Adı: Journal of Midwifery and Health Sciences
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.309-316
  • Anahtar Kelimeler: Acute low back pain, analgesic efficacy, ibuprofen, intravenous, randomized controlled trial
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: This study aimed to compare the analgesic efficacy of intravenous (IV) ibuprofen at doses of 400 mg and 800 mg for acute mechanical low back pain. Methods: A Prospective, randomized, double‐blind controlled clinical trial design was employed. Patients with moderate to severe acute low back pain were recruited from emergency departments. Ethical approval was obtained, and patients provided written consent. The study adhered to ethical guidelines and Good Clinical Practice principles. Results: Of the 144 patients, demographic characteristics were similar between groups. The 800 mg IV ibuprofen group demonstrated superior analgesic efficacy compared to the 400 mg group, with no significant adverse effects reported. Conclusion: The study concludes that the 800 mg IV dose of ibuprofen was more effective in providing analgesia control for patients with acute mechanical low back pain at all time intervals except for the 30th minute.