Investigation of the radioprotective properties of Zingerone, Ibuprofen, and Sulfasalazine against neutron radiation damage


Aygün B., Genişel M., Sayyed M., KARABULUT A.

Radiation Physics and Chemistry, vol.210, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 210
  • Publication Date: 2023
  • Doi Number: 10.1016/j.radphyschem.2023.111003
  • Journal Name: Radiation Physics and Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, INSPEC, Metadex, Pollution Abstracts, Civil Engineering Abstracts
  • Keywords: Active substances, Drug, Geant4, Neutron, Zingerone
  • Ataturk University Affiliated: Yes

Abstract

Nuclear radiation (neutron, gamma X rays, etc.) is widely used in power generation, industry, medicine, research, and agriculture. Exposure to ionizing or indirect ionizing radiation can cause mutagenetic cell death depending on the dose and duration. It is important to reduce the carcinogenesis of cancer patients undergoing radiotherapy treatment and people working in radiation fields. Neutrons have wide applications in neutron activation analysis (NAA), neutron capture therapy (NCT), neutron radiography (NR), neutron capture, neutron conversion doping (NTD) sample irradiation, and neutron diffraction (ND). In these applications, protective substances are needed to stop the neutrons from entering the body and to reduce their effects. In this work, the use of zingerone, ibuprofen, and sulfasalazine compounds as active ingredients in a neutron protective drug was investigated. Some important neutron attenuation parameters such as an effective removal cross section, mean free path, half-value layer, and transmission number were theoretically calculated with the Monte Carlo simulation GEANT4 code for fast and epithermal neutrons.The 241Am-Be fast neutron source and a BF3 gaseous detector were used to determine the neutron absorption ability of all of the samples. All of the results were compared with paraffin, which has a good shielding capacity. According to the results, it was found that every examined sample had a fast and epithermal neutron absorption capacity. It reported that the dose amount from the source was absorbed by the samples at rates of 33.37% (DAI1), 34.85% (DAI2), and 34.21% (DAI3). It was determined that the DAI2 sample in particular had a high absorption ability ratio compared to other samples. Because this sample have high hydrogen content than others samples. So, it was shown that these compounds can be used as active substances to make a radioprotective drug.