The assessment of genotoxic effects in lymphocyte cultures of infants treated with chloral hydrate

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Atıf İçin Kopyala

İKBAL M., TAŞTEKİN A., Dogan H., Pirim İ., ÖRS R.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, cilt.564, sa.2, ss.159-164, 2004 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 564 Sayı: 2
• Basım Tarihi: 2004
• Doi Numarası: 10.1016/j.mrgentox.2004.08.007
• Dergi Adı: MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.159-164
• Atatürk Üniversitesi Adresli: Evet

Özet

Chloral hydrate is a sedative commonly used in pediatric medicine. It was evaluated for genotoxicity in cultured peripheral blood lymphocytes of infants who were given chloral hydrate for sedation. Sister chromatid exchange and micronucleus frequencies were determined before and after chloral hydrate administration. After treatment, the frequencies of sister chromatid exchange and micronuclei were significantly increased, suggesting that chloral hydrate has moderate genotoxic potential in infants. (C) 2004 Elsevier B.V. All rights reserved.