An investigation of the antiinflammatory effects of an extract from Cladonia rangiformis HOFFM

SULEYMAN H., YILDIRIM D., ASLAN A., GOCER F., GEPDIREMEN A., Guvenalp Z.

BIOLOGICAL & PHARMACEUTICAL BULLETIN, cilt.25, sa.1, ss.10-13, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1248/bpb.25.10
  • Dergi Adı: BIOLOGICAL & PHARMACEUTICAL BULLETIN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.10-13
  • Anahtar Kelimeler: Cladonia rangiformis, antiinflammatory effect, rat, KININ RECEPTORS, PAW EDEMA, INFLAMMATION, BRADYKININ, ACID, RAT, PROSTAGLANDINS, ANTAGONISTS, SKIN
  • Atatürk Üniversitesi Adresli: Evet

Özet

In this study, the antiinflammatory effects of 50, 100 and 200 mg/kg doses of extract obtained from Cladonia rangiformis, so-called C-1, were investigated. The effects of C-1 on the acute phase of inflammation were studied in formaldehyde-induced edema. A cotton-pellet granuloma test was used to investigate the effects of C-1 on chronic inflammation. The antiedema potency of C-1 was compared with indomethacin. C-1 at the doses mentioned above showed 33.8% (p <0.005), 36.1% (p <0.005), 43.1% (p <0.001) inhibition, respectively. The corresponding antfinflammatory effect for indomethacin was determined as 72% (p <0.001). 200mg/kg C-1 and 10 mg/kg indomethacin decreased the formation of granuloma tissue induced by cotton-pellet method at a rate of 57.3% (p <0.005) and 52.1% (p <0.005), respectively. It was seen that C-1 was more effective on chronic inflammation than on acute inflammation.