Effects of sleep deprivation, nicotine, and selenium on wound healing in rats

Gumustekin K., Seven B., Karabulut N., Aktas O., Gursan N., Aslan S., ...Daha Fazla

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.114, ss.1433-1442, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 114
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1080/00207450490509168
  • Dergi Adı: INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1433-1442
  • Anahtar Kelimeler: nicotine, selenium, sleep deprivation, wound healing, INDUCED OXIDATIVE STRESS, MURINE L1210 CELLS, RHAMNOIDES-L., VITAMIN-E, DIMENSIONS, PATTERNS, TRAUMA, COPPER, TISSUE, DAMAGE
  • Atatürk Üniversitesi Adresli: Evet

Özet

Effects of sleep deprivation (SD), nicotine, and selenium (Se) on wound healing were studied in 50 male rats (Sprague-Dawley strain). Full-skin-thickness burns were produced in animals. Then, SD, nicotine, and Se administrations were applied to animals in different groups. Wound healing was assessed by pathological analysis of wound by counting,fibroblasts, capillary vessels, polymorphonuclear leucocytes (PNLs), and by measuring radiolabeled immunoglobulin G (IgG) amount in wound area by radio-pharmaceutical and immunoscintigraphic procedures. The number of,fibroblasts and capillary vessels were higher in control and Se groups than in sleep deprivation and nicotine groups, and the number of PNLs and the radiolabeled polyvalent IgG levels were higher in SD and nicotine groups than in control and Se groups. The results suggest that SD and nicotine may delay wound healing and that Se supplementation may accelerate wound healing by preventing nicotine-induced oxidative stress and lipid peroxidation.