Comparisons of analgesic effects of different doses of morphine and morphine plus methylprednisolone after knee surgery
EUROPEAN JOURNAL OF ANAESTHESIOLOGY, cilt.22, sa.8, ss.603-608, 2005 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 22 Sayı: 8
- Basım Tarihi: 2005
- Doi Numarası: 10.1017/s0265021505001018
- Dergi Adı: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.603-608
- Anahtar Kelimeler: morphine, methylprednisolone, orthopaedic surgery, knee, injections, intra-articular, postoperative period, pain, postoperative, INTRAARTICULAR MORPHINE, DOUBLE-BLIND, PAIN RELIEF, POSTOPERATIVE ANALGESIA, BUPIVACAINE, ARTHROSCOPY
- Atatürk Üniversitesi Adresli: Evet
Özet
Background: In this double-blind randomized study, the analgesic effects of morphine alone and with methylprednisolone were examined in 72 patients undergoing arthroscopic knee surgery. Methods: At the end of arthroscopy, patients were allocated randomly to one of four groups to receive intra-articular administrations of saline, morphine I mg, morphine 5 mg or morphine I mg with methylprednisolone 40 mg. Preoperative and postoperative pain levels at rest and during movement (active flexion of the knee) were measured by a visual analogue scale (VAS). Postoperative analgesic requirements to alleviate pain were evaluated. Results: Pain scores were significantly lower for the patients who received 5 mg morphine and I mg morphine with 40 mg methylprednisolone than for those who received saline or I mg morphine. This was accompanied by a decrease in the postoperative consumption of analgesics and prolongation of the duration of pain relief. Conclusions: This study confirms that the analgesic effect of morphine given intra-articularly is dose dependent and that combination of methylprednisolone with morphine has an additive effect on analgesia.