Comparisons of analgesic effects of different doses of morphine and morphine plus methylprednisolone after knee surgery

Kizilkaya M., Yildirim O., Ezirmik N., Kursad H., Karsan O.

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, cilt.22, sa.8, ss.603-608, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 8
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1017/s0265021505001018
  • Dergi Adı: EUROPEAN JOURNAL OF ANAESTHESIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.603-608
  • Anahtar Kelimeler: morphine, methylprednisolone, orthopaedic surgery, knee, injections, intra-articular, postoperative period, pain, postoperative, INTRAARTICULAR MORPHINE, DOUBLE-BLIND, PAIN RELIEF, POSTOPERATIVE ANALGESIA, BUPIVACAINE, ARTHROSCOPY
  • Atatürk Üniversitesi Adresli: Evet

Özet

Background: In this double-blind randomized study, the analgesic effects of morphine alone and with methylprednisolone were examined in 72 patients undergoing arthroscopic knee surgery. Methods: At the end of arthroscopy, patients were allocated randomly to one of four groups to receive intra-articular administrations of saline, morphine I mg, morphine 5 mg or morphine I mg with methylprednisolone 40 mg. Preoperative and postoperative pain levels at rest and during movement (active flexion of the knee) were measured by a visual analogue scale (VAS). Postoperative analgesic requirements to alleviate pain were evaluated. Results: Pain scores were significantly lower for the patients who received 5 mg morphine and I mg morphine with 40 mg methylprednisolone than for those who received saline or I mg morphine. This was accompanied by a decrease in the postoperative consumption of analgesics and prolongation of the duration of pain relief. Conclusions: This study confirms that the analgesic effect of morphine given intra-articularly is dose dependent and that combination of methylprednisolone with morphine has an additive effect on analgesia.