Synthesis and Carbonic Anhydrase Isoenzymes Inhibitory Effects of Brominated Diphenylmethanone and Its Derivatives

ÇETİNKAYA Y., Gocer H., GÜLÇİN İ., MENZEK A.

ARCHIV DER PHARMAZIE, cilt.347, sa.5, ss.354-359, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 347 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1002/ardp.201300349
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.354-359
  • Anahtar Kelimeler: Benzylalcohol, Bromination, Carbonic anhydrase, Enzyme inhibition, Reduction, ERYTHROCYTE ISOZYMES I, BROMOPHENOL DERIVATIVES, ANTIOXIDANT PROPERTIES, PHENOLIC-COMPOUNDS, ENZYME-ACTIVITY, ISOFORMS I, VITRO, VIVO, PURIFICATION, ACTIVATORS
  • Atatürk Üniversitesi Adresli: Evet

Özet

Known and novel derivatives including CO, Br, and OH (benzylic and phenolic), and the corresponding benzylic alcohols of (3,4-dimethoxyphenyl)(2,3,4-dimethoxyphenyl)methanone were synthesized, and their inhibitory effects on the carbonic anhydrase (CA) isoenzymes I and II were investigated. CAs are the metalloenzymes catalyzing the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3-). The inhibitory effects of diphenylmethanone derivatives 5-18 were tested on human CA (hCA, EC 4.2.1.1) isoenzymes (hCA I and hCA II) and they inhibited both isoenzymes at micromolar levels. Compounds 5 and 10 were found to be the best inhibitors against both CA isoenzymes. According to our data, compound 10 was the best inhibitor for isoenzyme hCA I (IC50=3.48 mu M, K-i=2.19 mu M) whereas compound 5 was found to be the best inhibitor for isoenzyme hCA II (IC50=1.33 mu M, K-i=2.09 mu M). Probably, stable conformations of 5 and 10 are more convenient for interaction with CA isoenzymes than those of the other compounds.