Role of Endothelin 1 on Proliferation and Migration of Human MCF-7 Cells

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Cinar I., Yayla M., Çelik M., Bilen A., Bayraktutan Z.

EURASIAN JOURNAL OF MEDICINE, cilt.52, ss.277-282, 2020 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5152/eurasianjmed.2020.20033
  • Dergi Adı: EURASIAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.277-282
  • Anahtar Kelimeler: Bosentan, cancer, ET-1, MCF-7, metastasis, HUMAN BREAST-CANCER, B RECEPTOR, EXPRESSION, GROWTH, BONE, METASTASIS, MECHANISMS, TUMOR
  • Atatürk Üniversitesi Adresli: Evet

Özet

Objective: The aim of this study was to explore the role of endothelin 1 (ET-1) in human breast cancer proliferation and migration and antagonism of endothelin receptor A (ETAR) and endothelin receptor B (ETBR) by using the non-selective dual ETA/ETB receptor antagonist bosentan and determine its anti-proliferative, anti-metastatic, and apoptotic effects demonstrated by nuclear factor kappa B (NF-kB), vascular endothelial growth factor (VEGF), Caspase 3 and Caspase 9 expression on endothelin-induced proliferation of MCF-7 cell line in vitro.