Role of Endothelin 1 on Proliferation and Migration of Human MCF-7 Cells
EURASIAN JOURNAL OF MEDICINE, cilt.52, ss.277-282, 2020 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 52
- Basım Tarihi: 2020
- Doi Numarası: 10.5152/eurasianjmed.2020.20033
- Dergi Adı: EURASIAN JOURNAL OF MEDICINE
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.277-282
- Anahtar Kelimeler: Bosentan, cancer, ET-1, MCF-7, metastasis, HUMAN BREAST-CANCER, B RECEPTOR, EXPRESSION, GROWTH, BONE, METASTASIS, MECHANISMS, TUMOR
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Atatürk Üniversitesi Adresli: Evet
Özet
Objective: The aim of this study was to explore the role of endothelin 1 (ET-1) in human breast cancer proliferation and migration and antagonism of endothelin receptor A (ETAR) and endothelin receptor B (ETBR) by using the non-selective dual ETA/ETB receptor antagonist bosentan and determine its anti-proliferative, anti-metastatic, and apoptotic effects demonstrated by nuclear factor kappa B (NF-kB), vascular endothelial growth factor (VEGF), Caspase 3 and Caspase 9 expression on endothelin-induced proliferation of MCF-7 cell line in vitro.