Akademik Veri Yönetim Sistemi
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, cilt.40, sa.3, 2023 (SCI-Expanded)
Background and aim: Tuberculosis and sarcoidosis are the two most important granulomatous diseases that physicians have difficulty differentiating. In our study, we aimed to observe the utility of systemic immune inflammation index (SII) in the differentiation of patients diagnosed by endobronchial ultrasound (EBUS)guided lymph node biopsy. Methods: Our study included 494 patients who presented to the chest diseases outpatient clinic of our hospital between 2015 and 2020 and underwent EBUS-guided biopsy for mediastinal lymphadenopathy (LAP). The patients' pre-procedural hematologic parameters and results of at least 2-year follow-up after diagnosis were retrospectively evaluated. Results: When compared by patient group, SII was significantly higher in patients with tuberculous lymphadenitis compared to those with sarcoidosis and reactive LAP (p=0.01 and <0.001, respectively) and in patients with sarcoidosis compared to those with reactive LAP (p=0.002). Among patients with sarcoidosis, platelet count, erythrocyte sedimentation rate, and SII were significantly higher in stage 2 patients compared to stage 1 patients, while lymphocyte levels were lower (p=0.009, 0.001, 0.001, and 0.001 respectively). In the ROC curve analysis of SII between patients with sarcoidosis and tuberculosis LAP, the area under the curve was 0.668. At a cut-off value of 890.7, SII had 70% sensitivity and 66% specificity in the differentiation of tuberculosis and sarcoidosis lymphadenitis. Conclusion: SII is an easily obtained parameter that may aid in the differentiation of tuberculosis and sarcoidosis LAP with granuloma and in the differentiation of granulomatous diseases from reactive LAP.