The role of iron and zinc in chemotherapy-induced alopecia

BUYUKAVCI M., GÜROL A., KARABULUT A., Budak G., KARACAN M.

JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER, cilt.95, sa.2, ss.255-261, 2005 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 95 Sayı: 2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.jqsrt.2004.11.017
  • Dergi Adı: JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.255-261
  • Anahtar Kelimeler: alopecia, children, chemotherapy, iron, zinc, TRACE-ELEMENTS, SCALP HAIR, MELATONIN, COPPER, EDXRF
  • Atatürk Üniversitesi Adresli: Evet

Özet

Chemotherapy-induced alopecia is a common and distressing side effect in children with cancer. Iron and zinc are the well known trace elements which are associated with hair shedding. In this study, we investigated the hair content of iron and zinc in children with cancer consists of two groups: group A, newly diagnosed patients; group B, the patients received a course of chemotherapy. We compared the results between each others and healthy controls. Hair content of iron and zinc was not different between the patient groups. Iron concentrations of patient samples, either at diagnosis or after chemotherapy, were significantly lower than healthy controls. However, there was no statistically significant difference between the groups regarding the zinc values. In conclusion, hair content of iron and zinc do not have a role in chemotherapy-induced alopecia. (c) 2005 Elsevier Ltd. All rights reserved.