Antidiabetic, anticholinergic and antioxidant activities of aerial parts of shaggy bindweed (Convulvulus betonicifolia Miller subsp.) – profiling of phenolic compounds by LC-HRMS

Creative Commons License

Bingol Z., Kızıltaş H., GÖREN A. C., Kose L. P., Topal M., DURMAZ L., ...Daha Fazla

Heliyon, cilt.7, sa.5, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1016/j.heliyon.2021.e06986
  • Dergi Adı: Heliyon
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Emerging Sources Citation Index (ESCI), Scopus, CAB Abstracts, Food Science & Technology Abstracts, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: Shaggy bindweed, Convulvulus betonicifolia, Antioxidant activity, Polyphenol content, LC-HRMS, IN-VITRO ANTIOXIDANT, LYOPHILIZED AQUEOUS EXTRACT, RADICAL SCAVENGING ACTIVITY, POLYPHENOL CONTENTS, ANTIMICROBIAL ACTIVITIES, ANTIRADICAL ACTIVITIES, ANALGESIC ACTIVITIES, ALPHA-AMYLASE, L., MS/MS
  • Atatürk Üniversitesi Adresli: Evet

Özet

© 2021 The Author(s)In order to evaluate the antioxidant activity of evaporated ethanolic extract (EESB) and lyophilized water extract (WESB) of Shaggy bindweed (Convulvulus betonicifolia Mill. Subs), some putative antioxidant methods such as DPPH· scavenging activity, ABTS•+ scavenging effect, ferric ions (Fe3+) reduction method, cupric ions (Cu2+) reducing capacity, and ferrous ions (Fe2+) binding activities were separately performed. Also, ascorbic acid, α-tocopherol and BHT were used as the standard compounds. Additionally, some phenolic compounds that responsible for antioxidant abilities of EESB and WESB were screened by liquid chromatography-high resolution mass spectrometry (LC-HRMS). At the same concentration, EESB and WESB demonstrated effective antioxidant abilities when compared to standards. In addition, EESB demonstrated IC50 values of 1.946 μg/mL against acetylcholinesterase (AChE), 0.815 μg/mL against α-glycosidase and 0.675 μg/mL against α-amylase enzymes.