Akademik Veri Yönetim Sistemi
JOURNAL OF HEALTH SCIENCES AND MEDICINE, cilt.6, sa.6, ss.1200-1204, 2023 (Hakemli Dergi)
Aims: Hidradenitis suppurativa (HS) is an inflammatory disease whose pathophysiology is not yet clearly known, but inflammatory
parameters have been used for many years in the diagnosis and follow-up. The aim of this study is to evaluate NLR, PLR, MHR, and
hemogram parameters in patients diagnosed with HS without comorbidities and compare them with healthy controls.
Methods: This study include 105 HS patients and 100 healthy volunteers. The medical records and laboratory findings of the participants
were reviewed retrospectively. Patients and control group neutrophils, lymphocytes, monocytes, platelets, mean platelet volume (MPV),
platelet distribution width (PDW), red cell distribution width coefficient of variation (RDW-CV), high-density lipoprotein cholesterol
(HDL-C), C-reactive protein (CRP), Neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio
(PLR), and MHR were compared.
Results: A total of 105 patients [43 (41%) women and 62 (59%) men] and one hundred healthy volunteers [52 (52%) women and 48 (48%)
men] participated in the study. The mean of neutrophil count (patient group=5.84±2.27, control group=4.29±1.81, p=0.001), lymphocyte
count (patient group=2.78±0.90, control group=2.31±0.63, p=0.001), monocyte count (patient group=0.74±0.39, control group=0.55±0.16,
p=0.001), platelet count (patient group=295.63±65.84, control group=274.45±59.06, p=0.007), CRP (patient group=12.71±24.38, control
group=2.61±2.21, p=0.039), and MHR (patient group=0.0203±0.0135, control group=0.0114±0.0056, p=0.001) were higher in the patient
whereas the mean of HDL-C (patient group=39.02±11.06, control group=52.85±16.46, p=0.001) and PLR (patient group=118.82±60.82,
control group=126.07±39.13, p=0.028) were significantly higher in control individuals. The adjusted effect of MHR, NLR, and PLR was
re-examined to eliminate the effect that may arise from the difference in age between patients and controls. It was observed that when
MHR increased by 0.01 unit, the risk of disease increased significantly by 4.07 times. When NLR increases by 1 unit, the disease increased.
significantly by 1.37 times. Both adjusted and unadjusted effects of MHR were significant. When the sensitivity and specificity of MHR, and
NLR in differentiating patients were examined, the sensitivity of MHR was found to be 67.4% and its specificity was 72.5% (p=0.001), while
the sensitivity of NLR was found to be 61.5% and its specificity was 74.0% ( p=0.038).
Conclusions: Our study showed that MHR was more effective in distinguishing HS patients than other inflammatory markers. MHR can be
used as a new marker to investigate the inflammatory effect of HS.