The critical role of spinal 5-HT7 receptors in opioid and non-opioid type stress-induced analgesia

YESILYURT, Ozgur; SEYREK, Melik; TASDEMIR, Serdar; KAHRAMAN, Serdar; DEVECI, Mehmet; Karakus, Emre; Halici, Zekai; DOGRUL, Ahmet

doi:10.1016/j.ejphar.2015.04.020

The critical role of spinal 5-HT7 receptors in opioid and non-opioid type stress-induced analgesia

YESILYURT O., SEYREK M., TASDEMIR S., KAHRAMAN S., DEVECI M. S., Karakus E., ...Daha Fazla

EUROPEAN JOURNAL OF PHARMACOLOGY, cilt.762, ss.402-410, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 762
Basım Tarihi: 2015
Doi Numarası: 10.1016/j.ejphar.2015.04.020
Dergi Adı: EUROPEAN JOURNAL OF PHARMACOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.402-410
Anahtar Kelimeler: 5-HT7 receptors, Stress-induced analgesia, Serotonin, DESCENDING SEROTONERGIC PATHWAYS, SWIM STRESS, ACTIVATION, ANTINOCICEPTION, PAIN, MECHANISM, MORPHINE, INVOLVEMENT, MODULATION, PEPTIDES
Atatürk Üniversitesi Adresli: Evet

Özet

The opioid and non-opioid types of stress-induced analgesia have been well defined. One of the non-opioid type involve the endocannabinoid system. We previously reported that the spinal serotonin 7 receptor (5-HT7) blockers inhibit both morphine and cannabinoid-induced analgesia, thus we hypothesized that descending serotonergic pathways spinal 5-HT7 receptor loop might contribute to stress induced analgesia.